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KMID : 0364920070320040134
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Journal of Radiation Protection and Research
2007 Volume.32 No. 4 p.134 ~ p.139
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RADIOPROTECTIVE EFFECT OF ALGIN-OLIGOSACCHARIDE THROUGH MEASURING CASPASE-3 AND CASPASE-9 IN MICE
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Choi Seong-Kwan
Chung Woon-Kwan
Lee Kyu-Soo
Jang Young-Il
Dong Kyung-Rae
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Abstract
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In order to find out the Radioprotective effect of algin-oligosaccharide(AOS), this study, with a mouse of which whole frame irradiated by 3 Gy radiation once, measured caspase-3 and caspase-9 amid cell signaling connected to apoptosis in order to observe cell activation. In Caspase-3 and Caspase-9 test for observing cell activation, both of Caspase-3 and Caspase-9 showed highly increased O.D. value in the irradiation control group, while the whole groups treated with algin-oligosaccharide before or after irradiation indicated lower O.D. value than the irradiation control group, especially showed big difference in 7 day’s treatment group of before irradiation (P<0.001). It confirmed that Caspase generation was restrained in AOS treatment group. Consequently, this study inquired into the fact that algin-oligosaccharide with superior antioxidant activity performed radiation protection by inducing restraint of Caspase generation and confirmed that natural product with less chemical toxicity was able to be applied as radioprotector.
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KEYWORD
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Algin-oligosaccharide, Radioprotective Effect, Caspase-3, Caspase-9
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